JERUSALEM / GAZA - A long-range surface-to-surface missile fired from Yemen struck an unpopulated area near Israel's international airport outside Tel Aviv on Sunday, Israeli sources said.

The missile triggered sirens in Tel Aviv and other cities in central Israel, sending residents running to shelters during the morning rush hour.

The Israeli military said in a statement that interceptors were launched but failed to shoot down the missile, which landed in an open area.

Israel's state-owned Kan TV news reported that the missile fell in Kfar Daniel, about 6 km from Ben Gurion Airport. A fire broke out in the area.

Magen David Adom, Israel's national rescue service, said five people were injured while running to shelters.

There were no changes to the Home Front Command's defensive guidelines for civilians.

The incident marks the second time a projectile from Yemen has reached central Israel, following a drone attack by Houthi forces in July that killed one person in Tel Aviv.

Meanwhile, at least 21 Palestinians were killed in Israeli airstrikes in the Gaza Strip on Saturday, said Palestinian security and medical sources.

An Israeli warplane struck a residential house in the al-Tuffah neighborhood east of Gaza City with at least one missile, Palestinian security sources told Xinhua.

The raid killed 10 Palestinians, including three children and a woman, said Palestinian medical sources.

In addition, the Palestinian Civil Defense said in a press statement that at least five Palestinians were killed in an Israeli airstrike near a school northwest of Gaza City.

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Six other people were killed in an Israeli shelling of a tent housing displaced people in the al-Mawasi area west of Khan Younis city in the southern Gaza Strip, according to local sources and eyewitnesses.

The Israeli army has not yet commented on these incidents.

Israel launched a large-scale offensive against Hamas in the Gaza Strip to retaliate against a Hamas rampage through the southern Israeli border on Oct 7, 2023, during which about 1,200 people were killed and about 250 taken hostage.

The Palestinian death toll from ongoing Israeli attacks in the Gaza Strip has risen to 41,182, Gaza-based health authorities said in a statement on Saturday.

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In addition, Gaza-based health authorities announced in a press statement the death of Palestinian paramedic Hamdan Abu Anaba inside an Israeli prison after the Israeli army arrested him in December 2023.

Palestinian medical sources told Xinhua that Abu Anaba once worked at the Nasser Medical Complex in Khan Younis and was arrested at the Netzarim checkpoint in the central Gaza Strip.

Also on Saturday, Hamas issued an urgent humanitarian appeal to save two million displaced people in the Gaza Strip before winter arrives.

"We are issuing an urgent humanitarian appeal to save two million displaced people in the Gaza Strip before it is too late, as winter approaches, weather conditions worsen, and the displaced people's tents deteriorate," the Hamas-run Gaza government media office said in a statement.

The statement noted that there are 543 shelter and displacement centers in the Strip due to the Israeli military's "forced displacement by compelling citizens to evacuate their homes and safe residential neighborhoods, which is a violation of international law."

According to the statement, 74 percent of the displaced people's tents have become unusable, and 100,000 out of 135,000 tents need immediate replacement.

It confirmed that these tents are completely dilapidated as they are made of wood, nylon, and fabric and have deteriorated due to the sun's heat and the climatic conditions in Gaza, becoming completely out of service.

The statement urged the international community and relevant organizations to act urgently and provide immediate relief to the displaced people.