MUSCAT/TEHRAN - Iran has agreed to Oman's proposal for holding the fifth round of indirect nuclear talks with the United States in Rome on Friday, Foreign Ministry spokesman Esmaeil Baghaei said on Wednesday.

In a statement, Baghaei said that the Iranian negotiating team was steadfast in pursuing and safeguarding the nation's rights and interests regarding the peaceful use of nuclear energy, including uranium enrichment and removal of the cruel sanctions, and would spare no effort or initiative to achieve those ends.

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The talks, aimed at reviving stalled diplomacy over Iran's nuclear program and US sanctions, are being facilitated by Oman. Four rounds have taken place since April, three in Muscat and one in Rome.

Iranian Foreign Minister Seyed Abbas Araghchi earlier said Tehran will "stand against excessive demands at the negotiating table, but we have never abandoned diplomacy". Araghchi added that uranium enrichment would continue "with or without an agreement".

He reiterated that Iran is prepared to offer transparency regarding its nuclear activities, but expects negotiations to also address the lifting of US sanctions and embargoes imposed on the country.

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Also on Wednesday, Iranian First Vice-President Mohammad-Reza Aref told a cabinet meeting in the Iranian capital Tehran that uranium enrichment on Iran's soil is the "red line" of Iran's establishment in its indirect talks with the United States.

US and Iranian officials have described the previous round of talks in Muscat on May 11 as "difficult but useful", noting a generally positive tone despite persistent differences.

US officials have in recent days called for Iran to fully halt uranium enrichment – an issue Tehran has repeatedly declared to be non-negotiable.