Tottenham's Harry Kane (left) vies for the ball with West Ham's Declan Rice during the English Premier League soccer match between Tottenham Hotspur and West Ham United at Tottenham Hotspur Stadium, in London, March 20, 2022. (DAVID CLIFF / AP)

Premier League clubs have voted in favor of reintroducing the use of five substitutes per game from the start of the 2022-23 season, the organization said on Thursday.

The substitutions can be made on three occasions during a game, not including halftime, and clubs can name nine substitutes in total on their team sheet, the league said in a statement.

Top flight clubs were allowed to increase the number of substitutes from three to five per match in the 2019-20 campaign when the league restarted in June after a three-month hiatus

Top flight clubs were allowed to increase the number of substitutes from three to five per match in the 2019-20 campaign when the league restarted in June after a three-month hiatus due to the COVID-19 pandemic.

Soccer's law-making body IFAB had recommended making the rule permanent, but the Premier League was the only top league in Europe to decide against continuing five substitutes from 2020-21 even as a number of managers voiced concerns about player fatigue.

The Professional Footballers' Association backed the league's latest decision, with chief executive Maheta Molango saying the increasing workload on players is damaging their health and wellbeing.

"The adoption of this rule is a welcome step forward in what needs to be an ongoing effort to address issues with player fatigue, making sure they have the opportunity to perform at their best," Molango said in a statement.

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Manchester United's Bruno Fernandes (second left) scores his side's second goal during the English Premier League soccer match between Leeds United and Manchester United, at Elland Road Stadium in Leeds, England, Feb 20, 2022. (JON SUPER / AP)

The Premier League added it would stop twice-weekly COVID-19 testing of players and staff from Monday, with only symptomatic individuals to be tested.

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"The wellbeing of players and staff remains a priority and the Premier League will continue to monitor the national COVID-19 situation and adapt League-wide protocols as required, in line with the latest guidance from public health authorities and medical experts," the statement said.

The Premier League also said the summer transfer window will open on June 10 and close on Sept 1.