PSG's Lionel Messi (right) tries to dribble past Marseille's Samuel Gigot during the French Cup soccer match between Olympique de Marseille and Paris Saint Germain at the Velodrome stadium in Marseille, southern France, on Feb 8, 2023. (PHOTO / AP)

MARSEILLE, France - Paris St Germain's miserable start to the year continued when they were knocked out of the French Cup last 16 by bitter rivals Olympique de Marseille on Wednesday.

Marseille, who had only beaten PSG twice since the capital side were taken over by Qatar Sport Investment (QSI) in 2011, reached the quarter-finals thanks to an Alexis Sanchez penalty and a Ruslan Malinovskyi thunderbolt after Sergio Ramos's first-half equalizer.

PSG have now lost three times already in 2023 and the Cup defeat comes less than a week before they take on Bayern Munich in their Champions League last-16 first leg.

Without the injured Kylian Mbappe, who will also miss the Bayern clash, PSG struggled and according to captain Marquinhos, they will now need to "shut (their) mouth and work" to bounce back.

"They pressed high and we did not manage to break the lines. It hurts because it was a Cup game against our great rival," Marquinhos added.

Without the injured Kylian Mbappe, who will also miss the clash against Bayern Munich in the Champions League, PSG struggled and according to captain Marquinhos, they will now need to "shut (their) mouth and work" to bounce back

Marseille coach Igor Tudor revelled in their victory.

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"Amazing guys, they're champions. It's awesome for the club," he said.

Marseille went ahead on 31 minutes when Sanchez converted a penalty after Cengiz Under had been brought down by Ramos, giving the hosts a deserved advantage after a lively start.

Ramos, however, made up for his mistake as he headed home Neymar's corner two minutes into first-half stoppage time, shortly after the Brazilian had hit the post with an 18-metre strike.

The Velodrome stadium then came to the boil when Malinovskyi, who joined on loan from Atalanta last month, beat Gianluigi Donnarumma with a vicious half-volley from just outside the box that went into the top corner.

Ramos had a goal disallowed for offside in added time in a nail-biting finale as Marseille defended tooth and nail.

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Elsewhere, Olympique Lyonnais knocked out Lille 4-2 on penalties after a 2-2 draw.

AJ Auxerre were beaten 3-2 at home by Ligue 2 side Rodez, who advanced after scoring with all three of their attempts on target.

The draw for the quarter-finals will be made on Thursday.